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By these substantial roles of Hsp90, eNOS activation and thus NO creation is often Increased by increased Hsp90 protein independent of modifications in whole eNOS protein. One example is, Harris et al. (229) observed greater eNOS exercise in mice next 10 wk of physical exercise training without having improve in abundance of full eNOS protein.

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The authors sincerely thank Emily Larson and Amy Bazzoni for guidance with preparation of your manuscript and all existing and previous laboratory users which have contributed to the operate described herein.

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